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KMID : 0043319980210050555
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.555 ~ p.558
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Isolation and Identification of Chondroitin Sulfates from the Mud Snail
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Lee Kyung-Bok
Kim Jong-Sig
Kwak Sang-Tae
Sim Won-Bo
Kwak Jong-Hwan
Kim Yeong-Shik
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Abstract
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chondroitin sulfates were isolated from the mud snail. For the quantitative analysis of enzymatic digestion products of isolated chondroitin sulfates, strong anion exchange-high performance liquid chromatography (SAX-HPLC) was performed. by the action of chondroitinase ABC, three unsaturated disaccharides$({\Delta}Di-OS), were produced from the mud snail chondroitin sulfates. The analysis showed that relative proportion of was 58.7/3.1/38.2. The immunomodulating activity of chondroitin sulfate was examined by cell proliferation assay and these results suggest that it might be a immunosuppressant.
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KEYWORD
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Mud snail, Cipangopaludina chinensis, Chondroitin sulfates, Proteoglycan, Anionexchange HPLC, Cell proliferation assay
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